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The Hanford study - a review ... (1984)

AuteurEthel S.Gilbert
Datumoktober 1984
Classificatie 3.01.8.43/09 (VS - LOCATIES - HANFORD)
Voorkant

Uit de publicatie:

THE HANFORD STUDY -- A REVIEW OF ITS LIMITATIONS AND CONTROVERSIAL CONCLUSIONS

Ethel S. Gilbert
Pacific Northwest laboratory

ABSTRACT

The Hanford data set has attracted attention primarily because of analyses 
conducted by Mancuso, Stewart, and Kneale (MSK). These investigators claim that 
the Hanford data provide evidence that our current estimates of cancer mortality 
resulting from radiation exposure are too low, and advocate replacing estimates 
based on populations exposed at relatively high doses (such as the Japanese atomic 
bomb survivors) with estimates based on the Hanford data. In this paper, it is shown 
that the only evidence of association of radiation exposure and mortality provided by 
the Hanford data is a small excess of multiple myeloma, and that this data set is not 
adequate for reliable risk estimation. It is demonstrated that confidence limits for 
risk estimates are very wide, and that the data are not adequate to differentiate 
among models. The more recent MSK analyses, which claim to provide adequate 
models and risk estimates, are critiqued.

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