Publication Laka-library:
Biological damage from ra nuclei incorporated....protection (1979)
| Author | L.Feinendegen |
| Date | 1979 |
| Classification | 6.01.4.00/06 (RADIATION - GENERAL) |
| Front | 
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From the publication:
BIOLOGICAL DAMAGE FROM RADIOACTIVE NUCLEI INCORPORATED INTO DNA OF CELLS; IMPLICATIONS FOR RADIATION BIOLOGY AND RADIATION PROTECTION L.E. Feinendegen Abstract Radionuclides with short or very short range emission cause biological effects the severity of which largely depends on the degree of distribution of the radionuclide between various organs, cells, and subcellular structures. Decisive here is the spatial congruence between site of decay and of energy absorption and radiosensitive structure. Amongst the many biological entities the most sensitive structure and therefore the critical structure appears to be the nucleus of the stern cell. Stern cells are distributed throughout the body; yet their concentration may vary from one organ tissue to another. Within the stern cell nucleus the critical molecule is the DNA. Radionuclides with very short range emissions and which exert any kind of transmutation effect are therefore most damaging when directly incorporated into the DNA of stern cell nuclei.
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